Research Summary
We are interested in using publicly available structural and biological databases to analyze the characteristics of protein binding sites. Families of proteins that bind similar drugs/ligands and families that use a similar architecture to bind alternative drugs/ligands may offer clues about evolutionary trends in protein structure and also offer clues into the design of novel binding sites. We develop our own computer tools to analyze our databases as well as using publicly available software when available and appropriate.
J.C.PIZARRO,B.VULLIEZ-LE NORMAND,M.-L.CHESNE-SECK, C.COLLINS,C.WITHERS-MARTINEZ, F.HACKETT, M.BLACKMAN, B.FABER, E.REMARQUE, C.H.M.KOCKEN,A.W.THOMAS, G.A.BENTLEY SCIENCE V. 308-408 2005
The apical membrane protein is a current target for vaccine developemnt. The protein appears on the parasite's cell surface before infection of red blood cells. Highlighted regions are areas thought to be important in the proteins function.