Important Note:
This course requires several prerequisites. I expect that you have a thorough understanding of fundamentals of Biology & Chemistry, Organic Chemistry and Genetics. To ensure your progress in the class, you are recommended to refresh your memories with topics related to Gene Expression before joining the class. You should be well grounded about the structure of DNA, RNA and Proteins. You should also have in depth knowledge of DNA replication transcription and translation. This information can be found in text books of Genetics and other Biology books. Several websites, including http://gslc.genetics.utah.edu/units/basics/ and http://www.roche.com/pages/genedcd6/English/TitleSequence/TitleSeq.html are also useful.
Click on the topic-links below to open the documents containing the lecture-outlines / handouts for the listed topic. You may need a password to open some of the documents. Contact me if you need to know the password. The links will become ALIVE a few days before the scheduled lecture.
You would need Acrobat Reader to open some of the files. Click Here if you want to download free Adobe Acrobat Reader.
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Topic |
| 1. | Lecture Syllabus |
| 2. |
Storage and Expression of Genetic Information (Self Reading Assignment)
|
| 3. | Structure and Function of Proteins (Self Reading Assignment) |
| 4. | Molecular Structure of Eukaryotic and Prokaryotic Genes |
| 5. | Sequence Alignment methods |
| 6. | Database Searching methods |
| 7. | Multiple Sequence Alignments |
| 8. | Basic concepts for Structure predictions (Self Reading Assignment) |
| 9. | Methods for Secondary Structure prediction |
| 10. | Tertiary and Quaternary Structure |
| 11. | Protein folding models and Structure prediction |
| 12. | Prediction of RNA Secondary Structures |
| 13. | Introduction to Genomics |
| 14. | Prokaryotic Genomes and Gene Recognition |
| 15. | Eukaryotic Genomes and Gene Recognition |
| 16. | Gene Expression analysis and Microarrays |
| 17. | Proteomics: Protein Classification |
| 18. | Proteomics: Techniques |
| 19. | Post Translational Modification and other predictions |
| 20. | Inhibitors, Drug Design and Ligand Screening |
| 21. | Substitution Patterns |
| 22. | Molecular Phylogenetics |
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